Immune, metabolism and therapeutic targets in RA (Rheumatoid Arthritis)
نویسندگان
چکیده
Rheumatoid arthritis is a classic autoimmune disease, the pathogenesis of which closely linked to auto-reactivity immune cells and joint inflammation. Three cell types, namely T cells, macrophages fibroblast-like synoviocytes (FLS), play an important role in RA. Numerous studies have pointed metabolic reprogramming FLS RA arthritis, with alterations different pathways mainly producing shift from oxidative phosphorylation (OXPHOS) glycolysis, addition lipid metabolism amino acid are also altered cellular activation state. Metabolic changes regulated by metabolism-related signalling pathways, associated two representative mTOR pathway AMPK pathway. In RA, both activated or inhibited, through series cascade reactions, gene expressions ultimately induced, altering intracellular promoting pro-inflammatory functions (e.g. cytokine release phenotypes), inhibiting expression genes related tolerance. Targeting key components enzymes has emerged as new way finding drugs for many modulators targeting these targets been extensively studied their therapeutic effects this article, we focus on possible pathways.
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ژورنال
عنوان ژورنال: BIO web of conferences
سال: 2022
ISSN: ['2273-1709', '2117-4458']
DOI: https://doi.org/10.1051/bioconf/20225501016